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L-Arginine is a conditionally essential amino acid. In that role L-Arginine supports nitric oxide formation, which is important for healthy dilation of blood vessels, circulation, and blood flow. In trials, L-Arginine has demonstrated the potential to support endothelial function in blood vessels, platelet function, exercise tolerance, and sexual function. Typically the body is able to manufacture sufficient quantities of L-arginine. However, in certain conditions, such as aging, cardiovascular disease, and trauma, arginine synthesis is reduced and requirements increased. L-arginine is necessary for the synthesis of creatine phosphate (PCr), which is essential for the synthesis of ATP, the source of energy in the mitochondria, particularly in muscle tissue. Vitamin B-6 is included in this formulation and serves as an essential nutrient for the metabolism of amino acids in the body.