Methylcobalamin is the coenzyme form of Vitamin B-12 and is the form of Vitamin B-12 that exists in the body. Most other forms of Vitamin B-12 require some level of conversion once they are ingested. Methylcobalamin requires no conversion and is the most active and effective form of Vitamin B-12.
Vitamin B-12 is a member of the B-complex family of water-soluble vitamins. Of the various forms of Vitamin B-12 available, methylcobalain is more bioactive than cyanocobalamin which has to be converted by the liver to the active coenzyme form of methylcobalamin before it can function in the body. Methylcobalamin has numerous functions in the body including stimulating red blood cell production and aiding in the production of normal, healthy myelin which protects the nervous system and supports its function. Methylcobalamin also aids in the conversion of homocysteine to methionine and in supporting healthy homocysteine blood levels. Methylcobalamin is also noted for its ability to donate a methyl group to form SAMe which helps to support healthy brain function and liver detoxification. Low levels of Vitamin B-12 are often seen in vegetarians as plant foods lack Vitamin B-12. B-12 deficiency is also seen in the elderly as their ability to absorb Vitamin B-12 from food decreases with age. The proper absorption of Vitamin B-12 requires intrinsic factor which is secreted by cells in the stomach. Elderly individuals secrete less intrinsic factor and tend to absorb less Vitamin B-12 from their food as they age. Consuming a sublingual methylcobalamin lozenge helps to avert problems with absorption as the methylcobalamin is absorbed directly into the bloodstream as it dissolves in the mouth. The Methyl B-12 Lozenge provides significant amounts of Vitamin B-12 without the concern for diet and GI absorption. Vitamin B-6 and folic acid work synergistically with methylcobalamin to promote healthy blood homocysteine levels. Biotin, along with Vitamin B-12, helps support fatty acid, amino acid, and carbohydrate metabolism.